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Laboratory notes

Notes from the bench

Insights from our lab on testing methods, certificates of analysis, and the science behind independent verification.

Latest note

HPLC Method Validation: Accuracy, Precision, Linearity, and Reliability

Learn how HPLC method validation evaluates accuracy, precision, linearity, specificity, working range, detection limits, and analytical reliability.

By Matteo Bianchi, MSc28 October 202615 min read

Earlier notes

18 October 202610 min read

HPLC Chromatograms Explained: How to Read Peaks, Retention Times, and Purity

Learn how to interpret HPLC chromatograms, understand retention time, peak area, resolution, and peak shape, and assess chromatographic purity.By Arthur van der Meer, MScRead article27 September 20268 min read

Chemical Fingerprints: How Laboratories Identify an Unknown Substance

Laboratories rarely identify an unknown substance with a single test. HPLC, GC-MS, LC-MS, and NMR each supply different evidence, and a reliable result depends on combining them.By Arthur van der Meer, MScRead article14 September 20264 min read

What Is a Certificate of Analysis (CoA) and How Can You Verify It?

earn what a Certificate of Analysis (CoA) really tells you, how to verify its authenticity, and why document verification alone may not be enough to confirm the quality and identity of a material.Read article14 September 20265 min read

Beyond Detection: Key Strategies for Peptide Separation and Analysis

Discover how peptides are detected and analyzed, from chromatographic separation to mass spectrometry, and why combining analytical techniques can provide a more complete picture of peptide identity and purityRead article